Null anticarcinogenic effect of silymarin on diethylnitrosamine-induced hepatocarcinogenesis in rats
نویسندگان
چکیده
منابع مشابه
Null anticarcinogenic effect of silymarin on diethylnitrosamine-induced hepatocarcinogenesis in rats
The aim of this study was to investigate the anticarcinogenic effects of silymarin in diethylnitrosamine (DEN)-induced hepatocarcinogenic rat models. Severe and mild models of hepatocellular carcinoma (HCC) were generated by the intraperitoneal administration of 40 mg/kg DEN once a week for 18 weeks and 100 mg/kg DEN every 2 weeks for 6 weeks in male Wistar rats, respectively. In the severe and...
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Antitumor effects of metformin have recently emerged despite its original use for type II diabetes. In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC. Tumor foci were characterized by gross examination and by histopathological characteristics, including ...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2013
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2013.1391